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Johnson & Johnson Single Dose Covid 19 Vaccine – Free PDF Download

 

SINGLE DOSE

  • The US Food and Drug Administration (FDA) has said that the single-dose vaccine manufactured by Johnson & Johnson is safe and effective against SARS-CoV-2.
  • If it is authorised, it will become the third COVID-19 vaccine to be approved in the US.

How does the Johnson and Johnson vaccine for Covid-19 work?

  • This vaccine called Ad26.COV2.S uses some genetic material from the SARS-CoV-2 virus.
  • More precisely, it uses the genetic code to make the spike protein, the protrusions that can be seen on the surface of the virus. The spike protein is used by many vaccines since this is what the virus uses to bind with human cells and initiate infection.

How does the Johnson and Johnson vaccine for Covid-19 work?

  • Once the vaccine is injected into the body, the goal is to trigger the immune system to make antibodies against the disease. But since vaccines do not consist of the entire genetic material of the virus, the viral genetic material cannot make people sick.

How does the Johnson and Johnson vaccine for Covid-19 work?

  • In the case of Ad26.COV2.S, the viral vector used is an adenovirus (adenovirus 26), which causes the common cold. The vector too is genetically modified so that it cannot replicate and lead people to fall sick. There are other adenovirus-based vaccines, one for Ebola was approved by the European Medicines Agency in July 2020 and others for Zika, filovirus, HIV, HPV, malaria and respiratory syncytial virus are being investigated.

How is it different from other RNA vaccines?

  • The vaccine is provided as a refrigerated suspension in a multi-dose vial containing five doses that can be stored at 2°C to 8°C. Vials that are unpunctured can be stored between 9°C and 25°C for up to 12 hours.
  • After the first dose has been withdrawn, the vial should be held between 2° and 8°C for up to 6 hours or at room temperature (maximum temperature 25°C) for up to two hours. If not used within these time limits, the vial should be discarded.

How is it different from other RNA vaccines?

  • The one manufactured by Oxford-AstraZeneca is also a viral vector vaccine like Ad26.COV2.S and delivers the genetic code of the spike protein to the body, but what differentiates viral vectored vaccines from mRNA vaccines is that the genetic material to manufacture the spike protein and that of the virus (the vector) is stored in DNA rather than RNA.

How is it different from other RNA vaccines?

  • Once such a vaccine is administered, first the viral vector will infect the human cells and then deliver the DNA, which contains instructions to make the spike protein to the nucleus of the cell.

How is it different from other RNA vaccines?

  • What distinguishes Ad26.COV2.S from the ones manufactured by Moderna, Oxford/AstraZeneca and Pfizer-BioNTech is that it is delivered as a single-dose. Right now, the vaccines that are in use globally, which include Moderna, Oxford/AstraZeneca and Pfizer-BioNTech, are all administered in two doses a few weeks apart. A second booster dose is required to build stronger and longer immune memory.
  • Because its efficacy is at 66 per cent, the Ad26.COV2.S could be less effective than Moderna and Pfizer, which have showed vaccine efficacy of about 94 and 95 per cent, respectively.

 

 

 

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